Author(s)
Primary presenter: Jonathan Baskin, MD
Lauren Le Barron
Steve J.A. Majerus, PhD
Jeremiah Ukwela
Affiliation(s)
Case Western Reserve University (Baskin, Majerus, Ukwela, Le Barron) Cleveland VA Medical Center (Baskin, Majerus);
Abstract:
Background: Microvascular reconstruction has vastly improved outcomes in head & neck reconstruction. However, vessel occlusion remains a challenge with no easy options for obtaining high fidelity confirmation of normal anastomotic flow. A fully implanted device that accurately and remotely monitors flow post-operatively adds distinct clinical value
Learning
Objectives: Demonstrating a remote flexible pressure sensor (PFS) to extravascularly monitor blood flow following head and neck reconstruction.
Study
Objectives: In-vitro and in-vivo feasibility demonstration of a sensor to monitor pressure and flow in a large animal model.
Study Design: Prospective device development & testing.
Methods: FPS was tested in-vitro on a pulsatile vascular phantom against reference flow and pressure sensors. Stability testing was performed with the system simulating cardiac cycles. Acute in-vivo use was investigated around the carotid arteries of 5 young pigs. BP was manipulated using nerve stimulation and drugs while recording FPS data. SBP, DBP, HR, and RR were extracted and compared to gold standard arterial line data.[1]
Results: Benchtop testing demonstrated sensor BP and flow accuracy of 5 mmHg and 52 mL/min, with chronic stability of 3%. In pigs, the FPS pulse wave tracked the A-line in normotensive as well as in hypertensive & hypotensive states.[2] Hemodynamic waveform differences were apparent between the carotid FPS and the femoral A-line, but showed a strong correlation (r=0.92). HR from the FPS and reference matched within 5%.
Conclusions: The FPS , through acute use in pigs, demonstrated a unique potential for postoperative monitoring [and treatment] following microvascular head & neck reconstruction.