Author(s)
Benjamin F. Erhardt, MD
Kaitlin K. July, BS
Eric J. Johannesen, DO
Robert P. Zitsch, MD
Affiliation(s)
University of Missouri
Abstract:
Educational Objective: At the conclusion of this presentation, the participants should be able to understand the potential utility and non-inferiority of a novel laceration repair product, compared to standard permanent suturing. Objectives: To establish the utility of a novel noninvasive superficial laceration repair product, compared to standard suturing. Study Design: Prospective, randomized animal trial. Methods: 24 outbred mice were anesthetized per standard protocol and 2 separate longitudinal incisions through the epidermis and dermis were made. One side was closed with 3 simple interrupted 4-0 nylon sutures, the contralateral side was closed with Zitches and Zuture. Mice were separated into 4 groups of 6, harvested on days 3, 7, 14, and 21. Sutures and Zitches were removed on day 7. Wounds were examined and graded each day for: swelling, erythema, dehiscence, and discharge. Upon harvest, the areas of incision were excised and placed in 10% formaldehyde. These were randomized, evaluated histologically by a pathologist, and graded on: epithelization, inflammation, fibrosis, dehiscence, deep opening, residual material, and necrosis. Results: Gross examination revealed no statistically significant difference in graded swelling, erythema, dehiscence, or discharge. Histological analysis is underway. Conclusions: Zitches and Zuture appear to be grossly equivalent to traditional simple interrupted suturing of superficial lacerations in rodents. Histopathologic analysis is underway. Further investigation using a human model could provide additional validation.